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Contrave is a combination drug used for weight loss in those that are either obese or overweight with some weight-related illnesses.It combines low doses of bupropion and naltrexone. Both drugs have individually shown some evidence of effectiveness in weight loss, and the combination has been shown to have some synergistic effects on weight. buy contrave online
In September 2014, a sustained release formulation of the drug was approved for marketing in the United States under the brand name Contrave. The combination was subsequently approved in the European Union in the spring of 2015, where it is sold under the name Mysimba.It was approved in Canada under the Contrave brand name in 2018.
Uses of buy contrave online
Bupropion/naltrexone is approved to be used, in conjunction to exercise and dietary changes, in the long-term treatment of adults that are either:
-Overweight and have a body mass index of at least 27 kg/m2, and have at least one weight-related comorbidity, like type 2 diabetes or high blood pressure.
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How Contrave Works
Individually, contrave target pathways in the central nervous system that influence appetite and energy use.
Bupropion is a reuptake inhibitor and releasing agent of both norepinephrine and dopamine, and a nicotinic acetylcholine receptor antagonist, and it activates proopiomelanocortin (POMC) neurons in the hypothalamus which give an effect downstream, resulting in loss of appetite and increased energy output. The POMC is regulated by endogenous opioids via opioid-mediated negative feedback.
Naltrexone by contrast is a pure opioid antagonist, therefore further augmenting bupropion’s activation of the POMC.
Combined, bupropion/naltrexone has an effect on the reward pathway that results in reduced food craving. In 2009, Monash University physiologist Michael Cowley was awarded one of Australia’s top research honors, the Commonwealth Science Minister’s Prize for Life Scientist of the Year, in recognition of his elucidation of these pathways, which led to the development of the combination medication.
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